Institut de Pharmacologie Moléculaire et Cellulaire
	MEDIANTE Microarray and High Throughput Sequencing data manager

Nice Platform

Publication center

MEDIANTE is an academic initiative that provides user-friendly tools allowing the analysis of global expression data, as collected by DNA microarray experiments. MEDIANTE is the bioinformatics platform of the Resogen Program (RNG/MRC), which distributes to the French academic community Human and Mouse pangenomic DNA microarrays at a cost-effective price (Download RNG/MRC ordering procedure). As MEDIANTE was supported by grants from the French National Genopole network, all information about design and annotation of the probes and transcripts are public and free. As such, Mediante provides a public access to a uniform collection of 300.746 human and 212.218 mouse distinct oligonucleotides. MEDIANTE also provides visualization tools allowing an easy comparison of the bioinformatics properties of several microarray platforms (RNG/MRC, Affymetrix, Agilent, Illumina at the moment). The aims of the project are: - to distribute the information about our collections, - to provide tools for easy visualisation of hybridizations and rapid quality control of the experiments, - to fasten the validation of new specific or whole genome microarrays, - to link experimental data with other public initiatives, such as Bioconductor, or GEO. DNA microarrays are curently produced by three different plateforms : Nice/Sophia Antipolis, Evry and Strasbourg. Identical arrays are collaboratively developed by MRC laboratories in UK (TC Freeman, HGMP, Hinxton).

Pour avoir un accés complet à Mediante vous devez vous créer un compte Mot de passe oublié ? Login Password Mediante Medlab MicroRNA

Laboratory bioinformatic tools (MicroCible and MicroTopTable) dedicated to microRNA studies are accessible by submitting the form via the MicroRNA button and following the link to "bioinformatic tools" in the top menu.

If you make use of the data presented here, please cite the following publications

An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes Le Brigand K., Russell R., Moreilhon C., Rouillard J.M., Jost B., Amiot F., Magnone V., Bole-Feysot C., Rostagno P., Virolle V., Defamie V., Dessen P., Williams G., Lyons P., Rios G., Mari B., Gulari E., Kastner P., Gidrol X., Freeman T.C. and Barbry P. Nucleic Acids Res. 2006 Jul 19;34(12):e87.

MEDIANTE : a Web-based Microarray Data manager. Le Brigand K. and Barbry P. Bioinformatics. 2007 May 15;23(10):1304-6. Epub 2007 Mar 23.

Related publications

1. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Triboulet R, Mari B, Lin YL, Chable-Bessia C, Bennasser Y, Lebrigand K, Cardinaud B, Maurin T, Barbry P, Baillat V, Reynes J, Corbeau P, Jeang KT, Benkirane M. Science. 2007 Mar 16;315(5818):1579-82.

2. Expression profiling by whole-genome microarray hybridization reveals differential gene expression in breast cancer cell lines after lycopene exposure. Chalabi N, Satih S, Delort L, Bignon YJ, Bernard-Gallon DJ. Biochim Biophys Acta. 2007 Feb;1769(2):124-30. Epub 2007 Jan 31.

3. Transcriptional signature of epidermal keratinocytes subjected to in vitro scratch wounding, reveals selective roles for ERK1/2, P38 and PI3K signalling pathways. Fitsialos G, Chassot AA, Turchi L, Dayem MA, Lebrigand K, Moreilhon C, Meneguzzi G, Busca R, Mari B, Barbry P, Ponzio G. J Biol Chem. 2007 Mar 14.

4. Gene expression profiling in human gastric mucosa infected with Helicobacter pylori. Hofman VJ, Moreilhon C, Brest PD, Lassalle S, Le Brigand K, Sicard D, Raymond J, Lamarque D, Hébuterne XA, Mari B, Barbry PJ, Hofman PM Mod Pathol. 2007 Sep;20(9):974-89. Epub 2007 Jul 20.

5. A Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification. Paul A Lyons, Maria Koukoulaki, Alexander Hatton, Karen Doggett, Hayley B Woffendin, Afzal N Chaudhry, and Kenneth GC Smith. BMC Genomics. 2007; 8: 64. Published online 2007 March 5. doi: 10.1186/1471-2164-8-64.

6. An Ontology-based Approach to Support Text mining and Information Retrieval in the Biological Domain Khaled Khelif, Rose Dieng-Kuntz and Pascal Barbry Special Issue on Ontologies and their Applications of the Journal of Universal Computer Science (JUCS)

7. The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis A. Fadloun, D. Kobi, J.-C. Pointud, A. K. Indra, M. Teletin, C. Bole-Feysot, B. Testoni, R. Mantovani, D. Metzger, G. Mengus, et al. Development, August 15, 2007; 134(16): 2947 - 2958.

8. Development of a method for recovering rickettsial RNA from infected cells to analyze gene expression profiling of obligate intracellular bacteria. La MV, François P, Rovery C, Robineau S, Barbry P, Schrenzel J, Raoult D, Renesto P. J Microbiol Methods. 2007 Dec;71(3):292-7. Epub 2007 Oct 4.

9. Comparative genomic analysis of Tropheryma whipplei strains reveals that diversity among clinical isolates is mainly related to the WiSP proteins. La MV, Crapoulet N, Barbry P, Raoult D, Renesto P. BMC Genomics. 2007 Oct 2;8:349.

10. A comparative analysis of perturbations caused by a gene knock-out, a dominant negative allele, and a set of peptide aptamers. Abed N, Bickle M, Mari B, Schapira M, Sanjuan-España R, Robbe Sermesant K, Moncorgé O, Mouradian-Garcia S, Barbry P, Rudkin BB, Fauvarque MO, Michaud-Soret I, Colas P. Mol Cell Proteomics. 2007 Dec;6(12):2110-21. Epub 2007 Sep 4.

11. Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. Doghman M, Karpova T, Rodrigues GA, Arhatte M, De Moura J, Cavalli LR, Virolle V, Barbry P, Zambetti GP, Figueiredo BC, Heckert LL, Lalli E. Mol Endocrinol. 2007 Dec;21(12):2968-87. Epub 2007 Aug 30.

12. Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3? Pottier N, Chupin C, Defamie V, Cardinaud B, Sutherland R, Rios G, Gauthier F, Wolters PJ, Berthiaume Y, Barbry P, Mari B. Am J Respir Crit Care Med. 2007 Dec 1;176(11):1098-107. Epub 2007 Aug 2.

13. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. Cell. 2007 Jun 1;129(5):983-97. Erratum in: Cell. 2007 Jul 27;130(2):385.

14. Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta1 integrin-mediated pathway. Puissegur MP, Lay G, Gilleron M, Botella L, Nigou J, Marrakchi H, Mari B, Duteyrat JL, Guerardel Y, Kremer L, Barbry P, Puzo G, Altare F. J Immunol. 2007 Mar 1;178(5):3161-9.

15. Molecular basis of Tropheryma whipplei doxycycline susceptibility examined by transcriptional profiling. Van La M, Barbry P, Raoult D, Renesto P. J Antimicrob Chemother. 2007 Mar;59(3):370-7. Epub 2007 Feb 8.

16. Easy and fast detection and genotyping of high-risk human papillomavirus by dedicated DNA microarrays. Albrecht V, Chevallier A, Magnone V, Barbry P, Vandenbos F, Bongain A, Lefebvre JC, Giordanengo V. J Virol Methods. 2006 Nov;137(2):236-44. Epub 2006 Aug 1.

17. Global transcriptome analysis of Tropheryma whipplei in response to temperature stresses. Crapoulet N, Barbry P, Raoult D, Renesto P. J Bacteriol. 2006 Jul;188(14):5228-39.

18. Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells. Buscà R, Berra E, Gaggioli C, Khaled M, Bille K, Marchetti B, Thyss R, Fitsialos G, Larribère L, Bertolotto C, Virolle T, Barbry P, Pouysségur J, Ponzio G, Ballotti R. J Cell Biol. 2005 Jul 4;170(1):49-59. Epub 2005 Jun 27.

19. Live Staphylococcus aureus and bacterial soluble factors induce different transcriptional responses in human airway cells. Moreilhon C, Gras D, Hologne C, Bajolet O, Cottrez F, Magnone V, Merten M, Groux H, Puchelle E, Barbry P. Physiol Genomics. 2005 Feb 10;20(3):244-55. Epub 2004 Dec 14.

20. Coordinated regulation of genes for secretion in tobacco at late developmental stages: association with resistance against oomycetes. Hugot K, Rivière MP, Moreilhon C, Dayem MA, Cozzitorto J, Arbiol G, Barbry P, Weiss C, Galiana E. Plant Physiol. 2004 Feb;134(2):858-70. Epub 2004 Feb 5.

21. Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival. Fromigué O, Louis K, Dayem M, Milanini J, Pages G, Tartare-Deckert S, Ponzio G, Hofman P, Barbry P, Auberger P, Mari B. Oncogene. 2003 Nov 20;22(52):8487-97.

22. Sensing radiosensitivity of human epidermal stem cells Rachidi W (Rachidi, Walid), Harfourche G (Harfourche, Ghida), Lemaitre G (Lemaitre, Gittes), Amiot F (Amiot, Franck), Vaigot P (Vaigot, Pierre), Martin MT (Martin, Michele T.) RADIOTHERAPY AND ONCOLOGY 83 (3): 267-276 JUN 2007

23. Expression profiling by whole-genome microarray hybridization reveals differential gene expression in breast cancer cell lines after lycopene exposure Chalabi N (Chalabi, Nassera), Satih S (Satih, Samir), Delort L (Delort, Laetitia), Bignon YJ (Bignon, Yves-Jean), Bernard-Gallon DJ (Bernard-Gallon, Dominique J.) BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1769 (2): 124-130 FEB 2007.

Kévin LE BRIGAND, IPMC, Sophia-Antipolis (FRANCE) Pascal BARBRY, IPMC, Sophia-Antipolis (FRANCE)

MEDIANTE - RNG - UK MRC - CEA/SGF - IPMC - CNRS Valbonne Sophia-Antipolis